Benzopyrazines: Synthesis, Characterization and Evaluation as Aldose Reductase Inhibitors

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

BACKGROUND Aldose reductase, the first enzyme of the polyol pathway, is the key determinant for the pathogenesis of long term diabetic complications. Accordingly, its inhibition represents the major therapeutic strategy to treat this kind of pathologies. OBJECTIVES In this work we describe the synthesis and the functional evaluation of a number of spiro-oxazolidinone and spiro-morpholinone ac...

Activators and inhibitors of lens aldose reductase.

Aldose reductase in a highly purified state is unstable. It requires the presence of thiol groups to maintain it in an active form. The enzyme apparently exists in 3 forms, only one of which is active. Tetramethylene glutaric acid (TMG) is an effective aldose reductase inhibitor. However, a relatively high level of TMG is needed to depress dulcitol synthesis in the lens incubated in a galactose...

Aldose Reductase Inhibitors as Potential Therapeutic Drugs of Diabetic Complications

Diabetes mellitus has become a major health threat as a global rise in it has been seen. The chronic disease has afflicted over 171 million people worldwide in 2000 and the incidence is expected to grow steadily to 366 million by 2030. As of May 2008, an estimated 92 million adults in China of the most populous country were living with diabetes and 148 million adults with prediabetes [1]. Diabe...

Current status of aldose reductase inhibitors.

Synthesis and docking analysis of new heterocyclic system of tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b]quinolines as aldose reductase inhibitors

Objective(s):In recent years, the chemistry of Tetrazolo[5',1':2,3][1,3,4]thiadiazepino [7,6-b]quinolines have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity. As the inhibitor of aldose reductase, the aforementioned compounds may have implication in preventing complications of diabetes. Materials...